STOP Sepsis Collaborative


Sepsis is the tenth leading cause of death in the United States. With an estimated 750,000 cases annually and a nearly 40 percent mortality rate, severe sepsis is also one of the most common causes of death in hospital critical care units. In addition to its high mortality rate, severe sepsis also bears a huge price tag, with a national estimate of $16.7 billion annually.

In the fall of 2010, the United Hospital Fund and Greater New York Hospital Association launched an initiative focused on the early identification and treatment of sepsis in hospital emergency departments. The central goal of the initiative—the STOP Sepsis Collaborative ("STOP" is an acronym for Strengthening Treatment and Outcomes for Patients)—was to reduce mortality in patients with severe sepsis and septic shock by implementing a protocol-based approach to case identification and rapid treatment. Improving communication and patient flow between emergency departments and intensive care units (ICUs) were a central feature of the project.

The more than 60 hospitals participating in the Collaborative achieved significant results, including an absolute reduction in inpatient mortality from severe sepsis of 22 percent from January 2011 to September 2012, better identification of sepsis, and better sepsis resuscitation in the emergency department.  

The Fund and GNYHA later expanded the Collaborative to include two additional areas of focus: reducing sepsis-related mortality for inpatients throughout the entire hospital and for pediatric patients.

As it had from its inception, the expanded Collaborative brought together experts throughout the region to develop model protocols, checklists, and data collection tools. The Fund and GNYHA assisted participating facilities by sponsoring periodic learning sessions and monthly conference calls, fostering dialogue among hospitals about best practices, and providing feedback on data submitted by hospitals so they could track their progress against their peers and other benchmarks.  

Project Contact: Deborah Halper


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